Sodium Hydroxide → HCID 69662367, compound

HRID 1828849Notes

Reaction equation

HRID 1828849 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[CH2:7][CH2:6]2.[C:13]1([C:19]2[C:23]([CH:24]=O)=[C:22]([CH3:26])[O:21][N:20]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[OH-].[Na+]>CCO.O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[C:7](=[CH:24][C:23]1[C:19]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[N:20][O:21][C:22]=1[CH3:26])[CH2:6]2

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 787875-Methoxyindan-1-oneHCID 27761445-Methyl-3-phenylisoxazole-4-carboxaldehyde

Product 1

HCID 69662367HCID 69662367, compoundYield 49%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

5-Methoxy-1-indanone (1 g, 6.2 mmol) and 3-phenyl-5-methyl-4-isoxazolecarbaldehyde (1.14 g, 6.2 mmol) were dissolved in EtOH (30 ml) and NaOH(4 drops of a 4M solution in water) was added. The reaction mixture was heated to reflux for 17 h. The reaction mixture was cooled and filtered to obtain the title compound as a yellow solid (1.0 g, 49%).

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 17 h
  3. temperatureThe reaction mixture was cooled
  4. filtrationfiltered

Sources & evidence

ORD record
ord-aeed545cf2a2440283b61cd371b3a231
Source dataset
uspto-grants-2006_06
Patent number
US07060710B2

Reaction notes

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