5-Nitrosalicylic acid → 2-Nitrophenol

HRID 1828864Notes

Reaction equation

HRID 1828864 reaction equation
[N+:1]([C:4]1[CH:12]=[C:8](C(O)=O)[C:7](O)=[CH:6][CH:5]=1)([O-:3])=[O:2].C1C=CC2N([OH:23])N=NC=2C=1.CC(C)N=C=NC(C)C>>[N+:1]([C:4]1[CH:12]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:23])([O-:3])=[O:2]

Participants

4

Reactant 3

HCID 73185-Nitrosalicylic acidHCID 12734DiisopropylcarbodiimideHCID 757711-Hydroxybenzotriazole

Product 1

HCID 69472-Nitrophenol

Procedure

This material was prepared from 5-nitrosalicylic acid (1c) (1 g, 5.46 mmol), HOBt (1 g, 7.4 mmol), DIC (1,3-diisopropylcarodiimide, 1 mL, 6.4 mmol), and an amino PEGA resin (1 g, 0.4 mmol) using a procedure similar to polystyrene resin (PS-2a).

Sources & evidence

ORD record
ord-e80926f4fb8345d0a58e5665d1aafb1b
Source dataset
uspto-grants-2006_06
Patent number
US07060752B2

Reaction notes

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