Glycine → Hippuric Acid

HRID 1828870Notes

Reaction equation

HRID 1828870 reaction equation
[N+]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1O)([O-])=O.[NH2:11][CH2:12][C:13]([OH:15])=[O:14].[C:16]([O-])(O)=[O:17].[Na+]>>[C:16]([NH:11][CH2:12][C:13]([OH:15])=[O:14])(=[O:17])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 3

HCID 750GlycineHCID 69472-NitrophenolHCID 516892Sodium Bicarbonate

Product 1

HCID 464Hippuric Acid

Procedure

To a nitrophenol resin (TG-2a) (10 mg, 3.5 μmol) was added 0.1 M glycin in 0.1 M NaHCO3. The reaction was stirred for 18 hours. The reaction mixture was filtered and washed with H2O. The washer was combined and acidified with acetic acid.

Workup

  1. filtrationThe reaction mixture was filtered
  2. washwashed with H2O

Sources & evidence

ORD record
ord-a0af75bf918345edbffe1dc4f42f3f73
Source dataset
uspto-grants-2006_06
Patent number
US07060752B2

Reaction notes

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