Ethanol → HCID 22059496, compound

HRID 1828888Notes

Reaction equation

HRID 1828888 reaction equation
O.[NH2:2][NH2:3].[CH3:4][C:5]1([CH3:16])[C:7]([CH3:9])([CH3:8])[CH:6]1[CH:10]([CH:14]=O)C([O-])=O.[CH2:17]([OH:19])C>>[CH3:16][C:5]1([CH3:4])[C:7]([CH3:8])([CH3:9])[CH:6]1[C:10]1[CH2:14][C:17](=[O:19])[NH:3][N:2]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 24654Hydrazine hydrate (1:1)HCID 86760103HCID 86760103, compound

Product 1

HCID 22059496HCID 22059496, compound

Procedure

Hydrazine hydrate (1.1 g, 0.024 mol) was added to a solution of ethyl 3-(2,2,3,3-tetramethylcyclopropyl-3-oxopropionate (4.41 g, 0.020 mol) in anhydrous ethanol (60 ml). The reaction mixture refluxed for 3 h. After cooling, the solvent was evaporated, and the residue was triturated with hexane to give a white solid.

Workup

  1. temperatureThe reaction mixture refluxed for 3 h
  2. temperatureAfter cooling
  3. customthe solvent was evaporated
  4. customthe residue was triturated with hexane
  5. customto give a white solid

Sources & evidence

ORD record
ord-c9c582ca88f34cc884ebca99994f77da
Source dataset
uspto-grants-2006_06
Patent number
US07060822B1

Reaction notes

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