Methanol → HCID 22059160, compound

HRID 1828891Notes

Reaction equation

HRID 1828891 reaction equation
C(O[C:4]([CH2:6][C:7]1[CH2:11][C:10](=[O:12])[NH:9][N:8]=1)=O)C.[C-:13]#[N:14].[Na+].C[OH:17]>N>[NH2:14][C:13]([CH2:4][CH2:6][C:7]1[CH2:11][C:10](=[O:12])[NH:9][N:8]=1)=[O:17]

Participants

5

Reactant 3

HCID 887MethanolHCID 8929Sodium CyanideHCID 14458246HCID 14458246, compound

Product 1

HCID 22059160HCID 22059160, compound

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Conditions

Temperature
45 °C

Procedure

A mixture of 3-(ethoxycarbonylmethyl)-2-pyrazolin-5-one (1 g, 5.8 mmol) and NaCN (28 mg, 0.58 mmol) in 30 ml of 9M ammonia in MeOH was heated to 45° C. in sealed tube for 3 days. After cooling, the solvent was evaporated and the residue was suspended in water. The precipitated solid was collected by filtration.

Workup

  1. temperatureAfter cooling
  2. customthe solvent was evaporated
  3. filtrationThe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-81f63d4f38e44213b61de7eb31ed8ed3
Source dataset
uspto-grants-2006_06
Patent number
US07060822B1

Reaction notes

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