Hydrogen Bromide → 3459-15-2

HRID 1828984Notes

Reaction equation

HRID 1828984 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH:12]([NH2:14])[CH3:13])[CH:6]=[CH:7][C:8]=1[O:9]C.[BrH:15]>ClCCl>[BrH:15].[NH2:14][CH:12]([CH3:13])[CH2:11][C:5]1[CH:4]=[C:3]([OH:2])[C:8]([OH:9])=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 8423(+-)-3,4-Dimethoxyamphetamine

Product 1

HCID 773286983459-15-2

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 2.0 g of 3A (2.01 mmol) was added 48% HBr, and the mixture was heated on a preheated oil bath for 3 hours under argon atmosphere. The reaction mixture was concentrated under reduced pressure to give thick oil. To the residue, 75 mL of dichloromethane was added and concentrated to dryness under reduced pressure. This was repeated four more times to give 2.3 g of 3B as light pink powder (M+H, 168).

Workup

  1. temperaturethe mixture was heated on a preheated oil bath for 3 hours under argon atmosphere
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customto give thick oil
  4. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-9ab2e05db34a4a4db8351f36bf7ce3b5
Source dataset
uspto-grants-2006_06
Patent number
US07060847B2

Reaction notes

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