Piperazine → 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine

HRID 1829129Notes

Reaction equation

HRID 1829129 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[C:13]([Cl:14])=[CH:12][C:11]([C:15]([F:18])([F:17])[F:16])=[CH:10][N:9]=1>O>[Cl:14][C:13]1[C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[N:9][CH:10]=[C:11]([C:15]([F:17])([F:16])[F:18])[CH:12]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 1122342,3-Dichloro-5-(trifluoromethyl)pyridine

Product 1

HCID 6676191-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazineYield 104.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
140 °C

Procedure

Piperazine (40 g) was melted by heating at 140° C. and 2,3-dichloro-5-trifluoromethylpyridine (10 g) was added thereto. The mixture was stirred at 120° C. for 2 hr. Water was added to the reaction mixture and the mixture was extracted with chloroform. The extract was washed with brine, dried and concentrated under reduced pressure to give 1-(3-chloro-5-trifluoromethyl-2-pyridyl)piperazine (12.8 g) as a brown solid.

Workup

  1. extractionthe mixture was extracted with chloroform
  2. washThe extract was washed with brine
  3. customdried
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-3c2547ab7e3c4934b4c42cc5b68c6f12
Source dataset
uspto-grants-2006_06
Patent number
US07060722B2

Reaction notes

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