Acetate → 2,2,4-Trimethyl-6-thiophen-3-yl-1,2-dihydroquinoline

HRID 182913Notes

Reaction equation

HRID 182913 reaction equation
[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH3:1][C:2]1([CH3:21])[NH:3][c:4]2[cH:5][cH:6][c:7]([O:13][S:14]([C:15]([F:16])([F:17])[F:18])(=[O:19])=[O:20])[cH:8][c:9]2[C:10]([CH3:12])=[CH:11]1.[F-:22].[K+:23].[O-:38][C:39]([CH3:40])=[O:41].[O-:42][C:43]([CH3:44])=[O:45].[Pd+2:37].[s:24]1[cH:25][c:26]([B:29]([OH:30])[OH:31])[cH:27][cH:28]1>>[CH3:1][C:2]1([CH3:21])[NH:3][c:4]2[cH:5][cH:6][c:7](-[c:26]3[cH:25][s:24][cH:28][cH:27]3)[cH:8][c:9]2[C:10]([CH3:12])=[CH:11]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 813Potassium CationHCID 8028TetrahydrofuranHCID 28179Fluoride IonHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 581760Thiophene-3-boronic acidHCID 20760320Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester

Product 1

HCID 225665322,2,4-Trimethyl-6-thiophen-3-yl-1,2-dihydroquinoline

Sources & evidence

ORD record
ord-4a2ead5b3ca743d58e6b4e04027dd51e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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