Piperazine → 1-(3,5-Dichloropyridin-2-yl)piperazine

HRID 1829133Notes

Reaction equation

HRID 1829133 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Cl[C:8]1[C:13]([Cl:14])=[CH:12][C:11]([Cl:15])=[CH:10][N:9]=1>O>[Cl:14][C:13]1[C:8]([N:1]2[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]2)=[N:9][CH:10]=[C:11]([Cl:15])[CH:12]=1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 27666Pyridine, 2,3,5-trichloro-

Product 1

HCID 27714311-(3,5-Dichloropyridin-2-yl)piperazineYield 101.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
140 °C

Procedure

Piperazine (24.0 g) was melted by heating at 140° C. and 2,3,5-trichloropyridine (5.00 g) was added thereto. The mixture was stirred at 120° C. for 2 hr. Water was added to the reaction mixture and the mixture was extracted with chloroform. The extract was washed with brine, dried and concentrated under reduced pressure to give 1-(3,5-dichloro-2-pyridyl)piperazine (6.43 g) as a brown solid.

Workup

  1. extractionthe mixture was extracted with chloroform
  2. washThe extract was washed with brine
  3. customdried
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-b171f1498f454a4b8374f6b8fa943ce1
Source dataset
uspto-grants-2006_06
Patent number
US07060722B2

Reaction notes

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