Piperazine → 1-(1-Phenyl-1H-tetrazol-5-YL)piperazine

HRID 1829138Notes

Reaction equation

Cl[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[N:4][N:3]=1.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[C:7]1([N:6]2[C:2]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[N:3][N:4]=[N:5]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

Reactant 2

HCID 4837Piperazine

HCID 842621H-Tetrazole, 5-chloro-1-phenyl-

Product 1

HCID 38255781-(1-Phenyl-1H-tetrazol-5-YL)piperazineYield 99.7%

Procedure

Using 5-chloro-1-phenyl-1H-tetrazol (2.10 g) and piperazine (10.0 g), and reaction at 100° C. in the same manner as in Example 196 (1), 1-(1-phenyl-1H-tetrazol-5-yl)piperazine (2.67 g) was obtained as a pale-yellow powder.

Sources & evidence

ORD record: ord-7f4e912189e146f887acfce08f0a79c1
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07060722B2

Reaction notes

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