Piperazine → HCID 22028625, compound

HRID 1829152Notes

Reaction equation

HRID 1829152 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([CH3:18])([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:10]=2)[N:7]=1.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[CH2:15]([O:14][C:12]([C:11]([C:9]1[N:10]=[C:5]2[CH:4]=[CH:3][C:2]([N:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)=[N:7][N:6]2[CH:8]=1)([CH3:18])[CH3:17])=[O:13])[CH3:16]

Participants

3

Reactant 2

HCID 4837PiperazineHCID 11043751Ethyl 2-(6-chloroimidazo[1,2-b]pyridazin-2-yl)-2-methylpropanoate

Product 1

HCID 22028625HCID 22028625, compoundYield 100%

Procedure

Using ethyl 2-(6-chloroimidazo[1,2-b]pyridazin-2-yl)-2-methylpropionate (2.00 g) and piperazine (19.7 g), and by a reaction at 100° C. in the same manner as in Example 196 (1), 1-[2-(1-ethoxycarbonyl-1-methylethyl)-6-imidazo[1,2-b]pyridazinyl]piperazine (2.37 g) was obtained as an oil.

Sources & evidence

ORD record
ord-e3886960fdb146788680dcbccdcdc84f
Source dataset
uspto-grants-2006_06
Patent number
US07060722B2

Reaction notes

Loading…