反应详情

A mixture of N-(1-Benzyl-4-phenyl-4-piperidinyl)acetamide (Bioorg. Med. Chem. Lett. 1996; 6(19); 2307) (49 g, 158 mmol), and palladium hydroxide (5 g) in methanol (600 ml) was hydrogenated at 50 psi and room temperature for 18 hours. The mixture was filtered, the filtrate concentrated under reduced pressure and the residue azeotroped with dichloromethane to give the title compound as a foam.

1. filtrationThe mixture was filtered
2. concentrationthe filtrate concentrated under reduced pressure
3. customthe residue azeotroped with dichloromethane