Acetic Anhydride → 1-Cyclohexyl-1-methylethyl propionate
Reaction equation
C[C:2]1(C)[CH2:7][CH2:6][CH2:5][CH:4]([C:8]([OH:11])([CH3:10])[CH3:9])[CH2:3]1.C[Mg]Cl.CC1(C)CCC[CH:19]([C:23](=[O:25])C)[CH2:18]1.C1(C(O)(C)C)CCCCC1.C(OC(=O)C)(=O)C.C(OC(=O)CC)(=O)CC>>[C:23]([O:11][C:8]([CH:4]1[CH2:3][CH2:2][CH2:7][CH2:6][CH2:5]1)([CH3:9])[CH3:10])(=[O:25])[CH2:19][CH3:18]Participants
7
Procedure
The following compounds were prepared analogously to the method described in Example 16, except that the alcohol component used was 2-(3,3-dimethylcyclohexyl)-2-propanol, [which can be prepared from methylmagnesium chloride and 1-(3,3-dimethylcyclohexyl)-ethanone by a Grignard reaction] instead of 2-cyclohexyl-2-propanol. The esterification was carried out with acetic anhydride (Example 18) or propionic anhydride (Example 19). Thus, only the spectroscopic data are indicated at this point:
Workup
- customThe following compounds were prepared analogously to the method
Sources & evidence
- ORD record
- ord-ec0827dca01e40d6ae21a2dce57a9f9e
- Source dataset
- uspto-grants-2006_06
- Patent number
- US07064102B2
Reaction notes
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