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HRID1829638

反应详情

EQUATION

反应方程式

HRID 1829638 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

2 次

结构：CCOC(C)=O
HCID8857

Ethyl acetate

C4H8O2

结构：[N-]=[N+]=[N-].[Na+]
HCID33557

未命名化合物

结构：C[C@]12CC[C@@H](N=[N+]=[N-])C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](C(=O)CBr)CC[C@@H]12
HCID86600186

未命名化合物

PRODUCTS

生成物

1
结构：C[C@]12CC[C@@H](N=[N+]=[N-])C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](C(=O)CN=[N+]=[N-])CC[C@@H]12
HCID10271373

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

结构：O.[Cl-].[Na+]
溶剂HCID57417360

Sodium chloride; water

ClH2NaO

PROCEDURE

实验过程

A solution of 3α-azido-21-bromo-5α-pregnan-20-one (35 mg, 0.083 mmol) in DMSO (3 mL) was treated with sodium azide (33 mg, 0.5 mmol) and the resulting mixture was stirred at RT for 24 h. Addition of water and ethyl acetate and extraction of the organic layer with water, brine, drying (Na2SO4) and evaporation of the solvent in vacuo afforded after purification of the residue using flash colunm chromatography with dichloromethane/ethyl acetate 90/10 as elution solvent the compound named above.

WORKUP

后处理

  1. customdrying
  2. custom(Na2SO4) and evaporation of the solvent in vacuo
  3. customafforded
  4. customafter purification of the residue
  5. washas elution solvent the compound