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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1829647Generated: November 1, 2026

Tolylboric acid → HCID 22053585, compound

https://huagongshe.com/reaction/1829647

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTolylboric acidHCID 13862916—
Reactant6-[3,5-bis(trifluoromethyl)benzyl]-4-chloro-2-(methylthio)-5-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-e][1,4]diazepinHCID 22053564—
ProductHCID 22053585HCID 22053585100%

Reaction Steps

In a similar manner to Reference Example 10, 6-[3,5-bis(trifluoromethyl)benzyl]-4-chloro-2-(methylthio)-5-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-e][1,4]diazepin (Compound of Reference Example 8; 2.36 g) was reacted with 2-methylphenylboric acid (816 mg) to obtain 6-[3,5-bis(trifluoromethyl)benzyl]-4-(2-methylphenyl)-2-(methylthio)-5-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-e][1,4]diazepin (2.63 g, 100%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07064119B2
Source datasetuspto-grants-2006_06
ORD IDord-31e0802a1c5941f2a3926292d147703b
Source noteuspto-grants-2006_06