Trifluoroacetic acid → HCID 22054410, compound

HRID 1829723Notes

Reaction equation

HRID 1829723 reaction equation
[CH3:1][C:2]1[C:6]([CH2:7][C:8]2[S:20][C:11]3[C:12]([CH2:18][CH3:19])=[N:13][N:14]([CH3:17])[C:15](=[O:16])[C:10]=3[C:9]=2[C:21](N2C[C@H](O)CO2)=[O:22])=[C:5]([CH3:29])[NH:4][N:3]=1.FC(F)(F)C(O)=[O:33]>>[CH3:29][C:5]1[C:6]([CH2:7][C:8]2[S:20][C:11]3[C:12]([CH2:18][CH3:19])=[N:13][N:14]([CH3:17])[C:15](=[O:16])[C:10]=3[C:9]=2[C:21]([OH:22])=[O:33])=[C:2]([CH3:1])[NH:3][N:4]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58649569HCID 58649569, compound

Product 1

HCID 22054410HCID 22054410, compound

Procedure

Prepared from the product of example 3, part g) (1.0 g) in trifluoroacetic acid (10 ml) under reflux for 20 hrs. The resulting mixture was evaporated under reduced pressure, azeotroping with dichloromethane (×3). The residue was triturated with water and then with ether, and the solid was collected and dried to give the subtitle compound as a solid (580 mg).

Workup

  1. temperatureunder reflux for 20 hrs
  2. customThe resulting mixture was evaporated under reduced pressure
  3. customazeotroping with dichloromethane (×3)
  4. customThe residue was triturated with water
  5. customwith ether, and the solid was collected
  6. customdried

Sources & evidence

ORD record
ord-025c2b504a9e45f48ed040ea6708a3ad
Source dataset
uspto-grants-2006_06
Patent number
US07064126B2

Reaction notes

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