Trifluoroacetic acid → 5-((1,4-diazepan-1-yl)methyl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine

HRID 1829920Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1829920
C1(S(CC2C=CN3C=2C(NC2C=CC(OCC4C=CC=C(F)C=4)=C(Cl)C=2)=NC=N3)=O)C=CC=CC=1.N1CCCNCC1.[NH2:43][CH:44]1[CH2:49][CH2:48][N:47]([CH2:50][C:51]2[CH:52]=[CH:53][N:54]3[C:59]=2[C:58]([NH:60][C:61]2[CH:66]=[CH:65][C:64]([O:67][CH2:68][C:69]4[CH:74]=[CH:73][CH:72]=[C:71]([F:75])[CH:70]=4)=[C:63]([Cl:76])[CH:62]=2)=[N:57][CH:56]=[N:55]3)[CH2:46][CH2:45]1.C(O)(C(F)(F)F)=O>CO>[Cl:76][C:63]1[CH:62]=[C:61]([NH:60][C:58]2[C:59]3=[C:51]([CH2:50][N:47]4[CH2:46][CH2:45][CH2:44][NH:43][CH2:49][CH2:48]4)[CH:52]=[CH:53][N:54]3[N:55]=[CH:56][N:57]=2)[CH:66]=[CH:65][C:64]=1[O:67][CH2:68][C:69]1[CH:74]=[CH:73][CH:72]=[C:71]([F:75])[CH:70]=1

Komponenten

6

Edukt 4

HCID 6422Trifluoroacetic acidHCID 68163Hexahydro-1,4-diazepineHCID 11698674N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-5-((4-aminopiperidin-1-yl)methyl)pyrrolo[1,2-f][1,2,4]triazin-4-amineHCID 22055282(5-Benzenesulfinylmethyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-amine

Produkt 1

HCID 220552625-((1,4-diazepan-1-yl)methyl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The title compound was prepared from 7B and excess homopiperazine by a route analogous to that used for the preparation of 7C. It had an analytical HPLC retention time=1.36 min. (YMC Xterra S7 C18, 3.0×50 mm column, 10–90% aqueous methanol over 2 minutes containing 0.1% TFA, 5 mL/min, monitoring at 220 nm)and a LC/MS M++1=481.

Quellen und Nachweise

ORD-Eintrag
ord-cc3fc8239f5b40b29010a5d6f345abc9
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07064203B2

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