HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5-((1,4-diazepan-1-yl)methyl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Hexahydro-1,4-diazepine | HCID 68163 | — |
| Reactant | N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)-5-((4-aminopiperidin-1-yl)methyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine | HCID 11698674 | — |
| Reactant | (5-Benzenesulfinylmethyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-[3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-amine | HCID 22055282 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-((1,4-diazepan-1-yl)methyl)-N-(4-(3-fluorobenzyloxy)-3-chlorophenyl)pyrrolo[1,2-f][1,2,4]triazin-4-amine | HCID 22055262 | — |
Reaction Steps
The title compound was prepared from 7B and excess homopiperazine by a route analogous to that used for the preparation of 7C. It had an analytical HPLC retention time=1.36 min. (YMC Xterra S7 C18, 3.0×50 mm column, 10–90% aqueous methanol over 2 minutes containing 0.1% TFA, 5 mL/min, monitoring at 220 nm)and a LC/MS M++1=481.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07064203B2 |
| Source dataset | uspto-grants-2006_06 |
| ORD ID | ord-cc3fc8239f5b40b29010a5d6f345abc9 |
| Source note | uspto-grants-2006_06 |