Trifluoroacetic acid → HCID 22055290, compound

HRID 1829938Notes

Reaction equation

HRID 1829938 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:16])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[N:14][CH:13]=[CH:12][N:11]=1.F[C:18](F)(F)C(O)=O>CO>[Cl:1][C:2]1[CH:3]=[C:4]([NH2:16])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[N:14][CH:13]=[C:12]([CH3:18])[N:11]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 22055274HCID 22055274, compound

Product 1

HCID 22055290HCID 22055290, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Compound 31A was prepared by a route analogous to that used for the preparation of Compound 16A. Analytical HPLC retention time=1.593 min. (Chromolith Speed ROD column 4.6×50 mm, 10–90% aqueous methanol over 4 minutes containing 0.2% trifluoroacetic acid, 4 mL/min, monitoring at 254 nm) and a LC/MS M++1=250+.

Sources & evidence

ORD record
ord-cf7e7f940c9a4774b2ab0dd49c207e72
Source dataset
uspto-grants-2006_06
Patent number
US07064203B2

Reaction notes

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