Ethanol → HCID 10290195, compound

HRID 1829994Notes

Reaction equation

[C:1]([CH2:4][NH:5][C:6]([C:8]1[N:12]([CH2:13][CH:14]2[CH2:16][CH2:15]2)[CH:11]=[C:10]([NH:17][C:18](=[O:44])[C:19]2[CH:43]=[CH:42][C:22]([C:23]([NH:25][C:26]3[CH:30]=[C:29]([C:31](=[O:37])[NH:32][CH2:33][C:34](=[NH:36])[NH2:35])[N:28]([CH2:38][CH:39]4[CH2:41][CH2:40]4)[CH:27]=3)=[O:24])=[CH:21][CH:20]=2)[CH:9]=1)=[O:7])(=[NH:3])[NH2:2].[CH2:45](N)[CH2:46]N.[CH2:49](O)[CH3:50]>>[CH:14]1([CH2:13][N:12]2[C:8]([C:6](=[O:7])[NH:5][CH2:4][C:1]3[NH:2][CH2:49][CH2:50][N:3]=3)=[CH:9][C:10]([NH:17][C:18](=[O:44])[C:19]3[CH:43]=[CH:42][C:22]([C:23]([NH:25][C:26]4[CH:30]=[C:29]([C:31](=[O:37])[NH:32][CH2:33][C:34]5[NH:35][CH2:45][CH2:46][N:36]=5)[N:28]([CH2:38][CH:39]5[CH2:40][CH2:41]5)[CH:27]=4)=[O:24])=[CH:21][CH:20]=3)=[CH:11]2)[CH2:16][CH2:15]1

Participants

Reactant 3

HCID 702Ethanol

HCID 3301Ethylenediamine

HCID 9894952HCID 9894952, compound

Product 1

HCID 10290195HCID 10290195, compoundYield 78%

Conditions

Temperature: 60 °C

Procedure

Compound 284 was dissolved in ethanol, 10 equivalents of ethylene diamine was added and the reaction mixture was heated at 60° C. for 15 hours. The solvent was evaporated and the target compound was purified by HPLC, the yield is 78%.

Workup

customThe solvent was evaporated
customthe target compound was purified by HPLC

Sources & evidence

ORD record: ord-df3c546b505849d7a1bb287e3500f6c8
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07064218B2

Reaction notes

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