1-Isopropylpiperazine → HCID 22055743, compound

HRID 1830037Notes

Reaction equation

HRID 1830037 reaction equation
[F:1][C:2]1[C:7](F)=[CH:6][C:5]([NH2:9])=[C:4]([N+:10]([O-:12])=[O:11])[CH:3]=1.[CH:13]([N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)([CH3:15])[CH3:14]>O>[F:1][C:2]1[C:7]([N:19]2[CH2:20][CH2:21][N:16]([CH:13]([CH3:15])[CH3:14])[CH2:17][CH2:18]2)=[CH:6][C:5]([NH2:9])=[C:4]([N+:10]([O-:12])=[O:11])[CH:3]=1

Participants

4

Reactant 2

HCID 780131-IsopropylpiperazineHCID 1571514,5-Difluoro-2-nitroaniline

Product 1

HCID 22055743HCID 22055743, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4,5-Difluoro-2-nitrophenylamine (1.0 equivalent) and N-isopropyl piperazine were heated at 100° C. for 3 hours. The solution was then cooled to room temperature and diluted with water. The resulting precipitate was filtered and dried under vacuum to provide title compound product. LC/MS (m/z) 283.2 (MH+), Rt 1.56 minutes.

Workup

  1. filtrationThe resulting precipitate was filtered
  2. customdried under vacuum

Sources & evidence

ORD record
ord-71846b919c2849edbe050114c8c88ed0
Source dataset
uspto-grants-2006_06
Patent number
US07064215B2

Reaction notes

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