m-Chloroperbenzoic acid → HCID 22053621, compound

HRID 1830054Notes

Reaction equation

HRID 1830054 reaction equation
[CH3:1][N:2]([CH2:10][C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[C:3](=[O:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6].ClC1C=CC=C(C(OO)=[O:25])C=1>ClCCl>[CH3:1][N:2]([CH2:10][C:11]1[CH:12]=[N+:13]([O-:25])[CH:14]=[CH:15][CH:16]=1)[C:3](=[O:9])[O:4][C:5]([CH3:8])([CH3:6])[CH3:7]

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 18939706HCID 18939706, compound

Product 1

HCID 22053621HCID 22053621, compoundYield 70.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of tert-butyl methyl(pyridin-3-ylmethyl)carbamate of Step A (0.50 g, 2.25 mmol) in dichloromethane (15 mL) was added 90% m-chloroperbenzoic acid (1.3 g, 6.8 mmol). After stirring overnight, the reaction was quenched with saturated aqueous sodium bicarbonate. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo to give 0.38 g of product as a colorless oil.

Workup

  1. customthe reaction was quenched with saturated aqueous sodium bicarbonate
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-b2381a0e45944100a92d0cac731240c2
Source dataset
uspto-grants-2006_06
Patent number
US07064120B2

Reaction notes

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