反应详情

A solution of 2-benzylsulfanylmethyl-acrylic acid (0.208 g) in methylene chloride (2.5 mL) was treated with thiolacetic acid and stirred at room temperature for 72 hours. The reaction mixture was diluted with ethyl acetate (50 mL) and then washed twice with water and once with saturated aqueous sodium chloride. After drying over magnesium sulfate the solvent was removed by rotary evaporation and the residue chromatographed on silica gel eluting with an ethyl acetate/hexane/acetic acid mixture to produce 3-acetylsulfanyl-2-benzylsulfanylmethyl-propionic acid (0.208 g).

1. washwashed twice with water and once with saturated aqueous sodium chloride
2. dry with materialAfter drying over magnesium sulfate the solvent
3. customwas removed by rotary evaporation
4. customthe residue chromatographed on silica gel eluting with an ethyl acetate/hexane/acetic acid mixture