Trifluoroacetic acid → HCID 86611130, compound

HRID 1830135Notes

Reaction equation

HRID 1830135 reaction equation
C([NH:8][CH:9]([CH2:23][CH3:24])[CH:10]([C:12]1[O:13][C:14]([C:17]2[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=2)=[N:15][N:16]=1)[OH:11])(OC(C)(C)C)=O.[C:25]([OH:31])([C:27]([F:30])([F:29])[F:28])=[O:26]>C(Cl)Cl>[OH:31][C:25]([C:27]([F:30])([F:29])[F:28])=[O:26].[NH2:8][CH:9]([CH2:23][CH3:24])[C:10]([C:12]1[O:13][C:14]([C:17]2[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=2)=[N:15][N:16]=1)=[O:11]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21962648HCID 21962648, compound

Product 1

HCID 86611130HCID 86611130, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Bocamino-1-(5-pyridin-4-yl-[1,3,4]oxadiazol-2-yl)-butan-1-ol (334 mg, 1 mmol) and MeCl2 (5 ml) were mixed and TFA (0.5 ml) was added at room temperature. After stirring for 1 hour, the solvent and excess TFA were removed under vacuum to produce 350 mg of 2-amino-1-(5-pyridin-4-yl-[1,3,4]oxadiazol-2-yl)-butan-1-one TFA salt.

Workup

  1. customthe solvent and excess TFA were removed under vacuum

Sources & evidence

ORD record
ord-8da2e4fd721046a38a6224d45d9bdb9a
Source dataset
uspto-grants-2006_06
Patent number
US07064123B1

Reaction notes

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