Methanol → HCID 86593100, compound

HRID 1830413Notes

Reaction equation

HRID 1830413 reaction equation
[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].CO.[N:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:37])[C:16]2[CH:21]=[C:20]([CH2:22][C:23]3[C:24](=[O:35])[C:25]([O:33][CH3:34])=[C:26]([O:31][CH3:32])[C:27](=[O:30])[C:28]=3[CH3:29])[CH:19]=[CH:18][C:17]=2[OH:36])=[CH:10][CH:9]=1>ClCCl>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[N:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:37])[C:16]2[CH:21]=[C:20]([CH2:22][C:23]3[C:24](=[O:35])[C:25]([O:33][CH3:34])=[C:26]([O:31][CH3:32])[C:27](=[O:30])[C:28]=3[CH3:29])[CH:19]=[CH:18][C:17]=2[OH:36])=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 6395Methanesulfonic AcidHCID 22054258HCID 22054258, compound

Product 1

HCID 86593100HCID 86593100, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Methanesulfonic acid (0.00914 g, 0.0951 mmol) was added to a methanol:dichloromethane mixed solution (1:1, 2 ml) of N-(pyridin-4-yl)-5-(5,6-dimethoxy-3-methyl-1,4-benzoquinon-2-yl)methyl-2-hydroxybenzamide (0.0370 g, 0.0906 mmol), and the solvent was removed by distillation. The obtained residue was recrystallized from a mixed solvent of methanol, ether and ethyl acetate (2:1:0.5) to obtain the titled compound (0.019 g, 0.0377 mmol, 42%).

Workup

  1. customThe obtained residue was recrystallized from a mixed solvent of methanol, ether and ethyl acetate (2:1:0.5)

Sources & evidence

ORD record
ord-c8e68e85139e4cff886d5bad8b5dab93
Source dataset
uspto-grants-2006_06
Patent number
US07064124B2

Reaction notes

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