Water → HCID 22048083, Verbindung

HRID 1830578Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1830578
Cl[C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([S:11][CH3:12])[C:3]=1[C:13]#[N:14].[CH2:15]([NH2:21])[C:16]1[O:20][CH:19]=[CH:18][CH:17]=1.C(N(CC)CC)C.O>C1COCC1>[CH2:15]([NH:21][C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([S:11][CH3:12])[C:3]=1[C:13]#[N:14])[C:16]1[O:20][CH:19]=[CH:18][CH:17]=1

Komponenten

6

Edukt 4

HCID 962WaterHCID 3438FurfurylamineHCID 8471TriethylamineHCID 220480807-Chloro-5-methylthiopyrazolo[1,5-a]pyrimidine-6-carbonitrile

Produkt 1

HCID 22048083HCID 22048083, VerbindungAusbeute 70,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

200 mg of 7-chloro-5-methylthiopyrazolo[1,5-a]pyrimidine-6-carbonitrile (compound No. 62) and 100 mg of furfurylamine were reacted in 5 ml of THF in the presence of 110 mg of triethylamine for about 30 minutes, then about 30 ml of water was added thereto, and the precipitated crystals were collected by filtration, washed with water and dried to obtain crude crystals. The crude crystals were washed with ether to obtain 180 mg of 7-furfurylamino-5-methylthiopyrazolo[1,5-a]pyrimidine-6-carbonitrile (compound No. 78) having a melting point of 110° C.

Aufarbeitung

  1. filtrationthe precipitated crystals were collected by filtration
  2. washwashed with water
  3. customdried
  4. customto obtain crude crystals
  5. washThe crude crystals were washed with ether

Quellen und Nachweise

ORD-Eintrag
ord-829d0cc077a543b092b9153363ebce53
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07067520B2

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