Pyrrolidine → HCID 22048130, compound

HRID 1830586Notes

Reaction equation

HRID 1830586 reaction equation
[NH:1]([C:8]1[C:13]([Br:14])=[CH:12][N:11]=[C:10]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][CH2:23]O)=[CH:18][CH:17]=2)[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1>>[NH:1]([C:8]1[C:13]([Br:14])=[CH:12][N:11]=[C:10]([NH:15][C:16]2[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][N:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)=[CH:18][CH:17]=2)[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 22048120HCID 22048120, compound

Product 1

HCID 22048130HCID 22048130, compound

Procedure

Using an analogous method to that described in Example 32, but starting from 4-anilino-5-bromo-2-[4-(2-hydroxyethyl)anilino]pyrimidine (Method 11) and pyrrolidine, the product was obtained. MS (MH+): 438.1, 440.1; HPLC (RT): 5.64.

Workup

  1. customthe product was obtained
  2. customHPLC (RT)

Sources & evidence

ORD record
ord-256986d08ee84854bc05827afe410192
Source dataset
uspto-grants-2006_06
Patent number
US07067522B2

Reaction notes

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