1,3-dimethyl-1H-indole-2-carbaldehyde → [(4-fluoro-1H-indol-3-yl)methyl](methyl)amine

HRID 18306Notes

Reaction equation

HRID 18306 reaction equation
BrC1C=C[C:5](NCC(OC)=O)=[N:6]C=1.[F:14][C:15]1[CH:23]=[CH:22][CH:21]=[C:20]2[C:16]=1[C:17]([CH:24]=O)=[CH:18][NH:19]2.CN1C2C(=CC=CC=2)C(C)=C1C=O>>[F:14][C:15]1[CH:23]=[CH:22][CH:21]=[C:20]2[C:16]=1[C:17]([CH2:24][NH:6][CH3:5])=[CH:18][NH:19]2

Participants

4

Reactant 3

HCID 27714681,3-dimethyl-1H-indole-2-carbaldehydeHCID 221390064-Fluoro-1H-indole-3-carbaldehydeHCID 22139049Methyl 2-((5-bromopyridin-2-yl)amino)acetate

Product 1

HCID 22139121[(4-fluoro-1H-indol-3-yl)methyl](methyl)amine

Procedure

According to the procedure of Preparation 13 (c), except substituting 4-fluoro-1H-indole-3-carboxaldehyde for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound was prepared as a viscous oil: MS (ES) m/e 179 (M+H)+.

Sources & evidence

ORD record
ord-d3fa868731a74581be3264abcefe2e9d
Source dataset
uspto-grants-2010_06
Patent number
US07741339B2

Reaction notes

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