tert-Butyldimethylsilyl chloride → HCID 22048157, compound

HRID 1830638Notes

Reaction equation

HRID 1830638 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([OH:9])=[C:4]([F:10])[CH:3]=1.[CH3:11][C:12]([Si:15](Cl)([CH3:17])[CH3:16])([CH3:14])[CH3:13]>>[C:12]([Si:15]([O:9][C:5]1[C:6]([F:8])=[CH:7][C:2]([Br:1])=[CH:3][C:4]=1[F:10])([CH3:17])[CH3:16])([CH3:14])([CH3:13])[CH3:11]

Participants

3

Reactant 2

HCID 28928tert-Butyldimethylsilyl chlorideHCID 27362924-Bromo-2,6-difluorophenol

Product 1

HCID 22048157HCID 22048157, compound

Procedure

The title compound was prepared by reacting 4-bromo-2,6-difluoro-phenol (10.54 g, 50.4 mmol) with TBDMS-Cl (9.88 g, 150.7 mmol) according to method E to yield 14.61 g (90%) of a clear, colorless, oil: 1H NMR (CDCl3) δ 0.17 (6H, s), 0.99 (9H, s), 7.02 (H, d, J=7.13 Hz).

Workup

  1. customto yield 14.61 g (90%) of a clear, colorless, oil

Sources & evidence

ORD record
ord-edf0eb8e2340404ab597799d3e73474c
Source dataset
uspto-grants-2006_06
Patent number
US07067524B2

Reaction notes

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