(4-Methoxyphenyl)boronic acid → HCID 22048158, compound

HRID 1830684Notes

Reaction equation

HRID 1830684 reaction equation
FC(F)(F)S(O[C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:18][CH3:19])[C:13]=2[Cl:17])[C:8]=1[Cl:20])(=O)=O.[CH3:23][O:24][C:25]1[CH:30]=[CH:29][C:28](B(O)O)=[CH:27][CH:26]=1>>[Cl:17][C:13]1[C:14]2[C:9](=[C:8]([Cl:20])[C:7]([C:28]3[CH:29]=[CH:30][C:25]([O:24][CH3:23])=[CH:26][CH:27]=3)=[CH:16][CH:15]=2)[CH:10]=[CH:11][C:12]=1[O:18][CH3:19]

Participants

3

Reactant 2

HCID 201262(4-Methoxyphenyl)boronic acidHCID 86589679HCID 86589679, compound

Product 1

HCID 22048158HCID 22048158, compound

Procedure

The title compound was prepared by 1,5-dichloro-6-methoxy-2-naphthyl trifluoromethanesulfonate (0.32 g, 0.85 mmol) with 4-methoxyphenyl boronic acid (0.18 g, 1.2 mmol) according to method A to yield 0.27 g (95%) of a white solid mp 146–149° C.;1H NMR (CDCl3): δ 3.88 (3H, s), 4.07 (3H, s), 7.02 (2H, d, J=8.73 Hz), 7.41 (1H, d, J=9.52 Hz), 7.46 (2H, d, J=8.83 Hz), 7.53 (1H, d, J=8.73 Hz), 8.19 (1H, d, J=8.73 Hz), 8.36 (1H, d, J=9.12 Hz);

Sources & evidence

ORD record
ord-8a7886ff45944677b352a9284f1ab47c
Source dataset
uspto-grants-2006_06
Patent number
US07067524B2

Reaction notes

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