Acetic Anhydride → HCID 23248656, compound

HRID 1830796Notes

Reaction equation

HRID 1830796 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=1)=[O:10].[C:18](OC(=O)C)(=[O:20])[CH3:19]>C1(C)C=CC=CC=1>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([NH:1][C:18](=[O:20])[CH3:19])=[C:3]([C:9](=[O:10])[C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=2)[CH:4]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 182478(2-Amino-5-bromophenyl)(3-chlorophenyl)methanone

Product 1

HCID 23248656HCID 23248656, compoundYield 120.2%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of intermediate (2) (0.328 mol) and acetic acid, anhydride (0.656 mol) in toluene (1200 ml) was stirred and refluxed for one night. The mixture was evaporated and the product was used without further purification, yielding 139 g (quant.) of N-[4-bromo-2-(3-chlorobenzoyl)phenyl]-acetamide (intermediate 3).

Workup

  1. temperaturerefluxed for one night
  2. customThe mixture was evaporated
  3. customthe product was used without further purification

Sources & evidence

ORD record
ord-0dd5cb84192341dc84bd928f2a81474b
Source dataset
uspto-grants-2006_06
Patent number
US07067531B2

Reaction notes

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