反应详情

The compound (25) (0.73 g, 5.61 mmol) was dissolved in ethyl acetate (15 ml) and 10% palladium carbon (20 mg) was added. The mixture was stirred at normal temperature and normal pressure under a hydrogen atmosphere for 2 hrs. for hydrogenation. The reaction mixture was passed through celite and the filtrate was partitioned between ethyl acetate and brine. The aqueous layer was extracted with ethyl acetate, and the extract was combined and dried (MgSO4). The solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography to give a colorless oil (0.62 g, 84%).

1. customthe filtrate was partitioned between ethyl acetate and brine
2. extractionThe aqueous layer was extracted with ethyl acetate
3. dry with materialdried (MgSO4)
4. customThe solvent was evaporated under reduced pressure
5. customThe obtained residue was purified by silica gel column chromatography