Methylamine → 4-Cyano-N-methylbenzamide

HRID 1830876Notes

Reaction equation

HRID 1830876 reaction equation
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][CH:4]=1)#[N:2].[CH3:12][NH2:13]>>[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH:13][CH3:12])=[O:8])=[CH:5][CH:4]=1)#[N:2]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 801724-Cyanobenzoyl chloride

Product 1

HCID 50807374-Cyano-N-methylbenzamide

Procedure

By the reaction in the same manner as in Example 26-i) using 4-cyanobenzoyl chloride (5.17 g) and 40% aqueous methylamine solution (20 ml), the title compound (4.13 g) was obtained as colorless powder crystals.

Workup

  1. customBy the reaction in the same manner as in Example 26-i)

Sources & evidence

ORD record
ord-00c68994901b49a1ba8ba9f0b6f8173e
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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