Acetic Anhydride → 4-Cyanoacetanilide

HRID 1830882Notes

Reaction equation

[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>>[C:6]([C:5]1[CH:8]=[CH:9][C:2]([NH:1][C:10](=[O:12])[CH3:11])=[CH:3][CH:4]=1)#[N:7]

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 133964-Aminobenzonitrile

Product 1

HCID 372564-Cyanoacetanilide

Procedure

By the reaction in the same manner as in Example 35-i) using 4-aminobenzonitrile (5.51 g) and acetic anhydride (5.7 ml), the title compound (5.88 g) was obtained as colorless needle crystals.

Workup

customBy the reaction in the same manner as in Example 35-i)

Sources & evidence

ORD record: ord-1df84c9342fb47e9bc65b20ae4ee56e8
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07067537B2

Reaction notes

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