HCID 22049743, compound → HCID 22049777, compound

HRID 1830891Notes

Reaction equation

HRID 1830891 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:10]=1[CH3:11])=O.[O:12]=[C:13]1[C:21]2[CH:20]=[CH:19][CH:18]=[C:17]([C:22](=[S:24])[NH2:23])[C:16]=2[CH2:15][NH:14]1>>[CH3:11][C:10]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[C:3]1[N:23]=[C:22]([C:17]2[CH:18]=[CH:19][CH:20]=[C:21]3[C:16]=2[CH2:15][NH:14][C:13]3=[O:12])[S:24][CH:2]=1

Participants

3

Reactant 2

HCID 22049743HCID 22049743, compoundHCID 220497832-Bromo-1-(4-methylpyridin-3-yl)ethan-1-one

Product 1

HCID 22049777HCID 22049777, compound

Procedure

By the reaction in the same manner as in Example 25-ii) using 1-oxo-4-isoindolincarbonitrile (310 mg), 1-oxoisoindolin-4-carbothioamide was obtained as pale-green powder. Then, by the reaction in the same manner as in Example 25-iii) using 2-bromo-1-(4-methylpyridin-3-yl)ethanone hydrobromate (520 mg) and 1-oxoisoindolin-4-carbothioamide, the title compound (51 mg) was obtained as colorless powder crystals.

Workup

  1. customThen, by the reaction in the same manner as in Example 25-iii)

Sources & evidence

ORD record
ord-a0c2094cd40145548d91fbe5e94e259f
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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