Ethylamine → HCID 22049742, compound

HRID 1830905Notes

Reaction equation

HRID 1830905 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]=[C:13]([C:16]3[CH:17]=[N:18][CH:19]=[CH:20][C:21]=3[C:22]([F:25])([F:24])[F:23])[S:14][CH:15]=2)=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)(Cl)=O.[CH2:30]([NH2:32])[CH3:31]>>[CH2:30]([NH:32][C:4](=[O:5])[C:3]1[CH:7]=[C:8]([C:11]2[N:12]=[C:13]([C:16]3[CH:17]=[N:18][CH:19]=[CH:20][C:21]=3[C:22]([F:24])([F:25])[F:23])[S:14][CH:15]=2)[CH:9]=[CH:10][C:2]=1[F:1])[CH3:31]

Participants

4

Reactant 3

HCID 6341EthylamineHCID 24386Thionyl ChlorideHCID 22049750HCID 22049750, compound

Product 1

HCID 22049742HCID 22049742, compound

Procedure

By the reaction in the same manner as in Example 60 using 2-fluoro-5-{2-[4-(trifluoromethyl)pyridin-3-yl]-1,3-thiazol-4-yl}benzoic acid (202 mg), thionyl chloride (0.06 ml) and aqueous ethylamine solution (70%, 5 ml), the title compound (139 mg) was obtained as colorless powder crystals.

Sources & evidence

ORD record
ord-4be9f7f5165b42818d99d9cabf712277
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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