Hydrochloric Acid → HCID 22049750, compound

HRID 1830918Notes

Reaction equation

HRID 1830918 reaction equation
[F:1][C:2]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][C:23]=3[C:24]([F:27])([F:26])[F:25])[S:16][CH:17]=2)=[CH:9][C:3]=1[C:4]([O:6]CC)=[O:5].[OH-].[Na+].Cl>C(O)C>[F:1][C:2]1[CH:12]=[CH:11][C:10]([C:13]2[N:14]=[C:15]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][C:23]=3[C:24]([F:27])([F:25])[F:26])[S:16][CH:17]=2)=[CH:9][C:3]=1[C:4]([OH:6])=[O:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22049705HCID 22049705, compound

Product 1

HCID 22049750HCID 22049750, compoundYield 92.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 2-fluoro-5-{2-[4-(trifluoromethyl)pyridin-3-yl]-1,3-thiazol-4-yl}benzoate (1.00 g) was suspended in a mixture of ethanol (20 ml)/1N NaOH (5 ml) and the mixture was stirred at room temperature for one hr. 1N Hydrochloric acid (5 ml) was added to the reaction mixture, and the precipitated crystals were collected by filtration and washed with water to give the title compound (0.86 g) as a pale-brown powder.

Workup

  1. filtrationthe precipitated crystals were collected by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-ba8d05d7bff24d99aadd32df6122c40a
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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