4-Methylpyridine-3-carbothioamide → HCID 22049790, compound

HRID 1830919Notes

Reaction equation

HRID 1830919 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][C:10]=1[CH3:11])=O.[CH3:12][C:13]1[CH:18]=[CH:17][N:16]=[CH:15][C:14]=1[C:19](=[S:21])[NH2:20]>>[CH3:11][C:10]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[C:3]1[N:20]=[C:19]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][C:13]=2[CH3:12])[S:21][CH:2]=1

Participants

3

Reactant 2

HCID 220497214-Methylpyridine-3-carbothioamideHCID 220497832-Bromo-1-(4-methylpyridin-3-yl)ethan-1-one

Product 1

HCID 22049790HCID 22049790, compoundYield 42%

Procedure

By the reaction in the same manner as in Example 25-iii) using 2-bromo-1-(4-methylpyridin-3-yl)ethanone hydrobromate (392 mg) and 4-methylpyridine-3-thiocarboxamide (152 mg), the title compound (112 mg) was obtained as colorless powder crystals.

Workup

  1. customBy the reaction in the same manner as in Example 25-iii)

Sources & evidence

ORD record
ord-af99d101f8f24d04bcd2cd8ac64fad21
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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