HCID 22047806, compound → HCID 178426979, compound

HRID 1831046Notes

Reaction equation

HRID 1831046 reaction equation
C[O:2][C:3]1[N:8]=[CH:7][C:6]([N:9]2[C:14](=[O:15])[CH2:13][C:12]([CH3:17])([CH3:16])[CH2:11][C:10]2=[O:18])=[CH:5][CH:4]=1>O1CCCC1>[OH:2][C:3]1[N:8]=[CH:7][C:6]([N:9]2[C:14](=[O:15])[CH2:13][C:12]([CH3:16])([CH3:17])[CH2:11][C:10]2=[O:18])=[CH:5][CH:4]=1

Participants

3

Reactant 1

HCID 22047806HCID 22047806, compound

Product 1

HCID 178426979HCID 178426979, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
190 °C

Procedure

6′-Methoxy-4,4-dimethyl-4,5-dihydro-3H-[1,3′]bipyridinyl-2,6-dione (2.56 g, 10.3 mmol) was dissolved in a mixture of tetrahydrofuran and diethyl ether. HCl-gas was bubbled into the solution for 5 minutes. More diethyl ether was added and the white precipitate was collected by suction, washed twice with diethyl ether and heated in a kugelrohr apparatus at 190° C. for 15 minutes yielding the title compound (2.16 g, 89% yield) as a white solid.

Workup

  1. customwas bubbled into the solution for 5 minutes
  2. additionMore diethyl ether was added
  3. customthe white precipitate was collected by suction
  4. washwashed twice with diethyl ether

Sources & evidence

ORD record
ord-ba83ba5baa7b4b27a144fce42937ee19
Source dataset
uspto-grants-2006_06
Patent number
US07067517B2

Reaction notes

Loading…