4-Chlorobenzoyl chloride → HCID 178522254, compound

HRID 1831062Notes

Reaction equation

HRID 1831062 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[NH2:11][C:12]1[CH:13]=[CH:14][C:15]([O:18]C)=[N:16][CH:17]=1>ClCCl>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:11][C:12]2[CH:17]=[N:16][C:15]([OH:18])=[CH:14][CH:13]=2)=[O:7])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 85014-Chlorobenzoyl chlorideHCID 811216-Methoxy-3-pyridinylamine

Product 1

HCID 178522254HCID 178522254, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-Chlorobenzoyl chloride (1.75 g, 10.0 mmol) was added carefully to a stirred solution of 5-amino-2-methoxypyridine (1.24 g, 10.0 mmol) in dichloromethane (10 mL). After stirring overnight at room temperature, the solvent is evaporated in vacuo and the residue is heated in a pre-heated kugelrohr oven at 200° C. for 5–10 minutes under house-vacuum (around 20 mbar) yielding the title compound, which was used without further purification.

Workup

  1. customthe solvent is evaporated in vacuo
  2. temperaturethe residue is heated in a pre-heated kugelrohr oven at 200° C. for 5–10 minutes under house-vacuum (around 20 mbar)

Sources & evidence

ORD record
ord-ac0c190924a845f5a681998b42cd194b
Source dataset
uspto-grants-2006_06
Patent number
US07067517B2

Reaction notes

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