Carbamic chloride, N-methyl-N-phenyl- → Methyl-phenyl-carbamic Acid 4-acetyl-2-carbamoyl-phenyl Ester

HRID 1831175Notes

Reaction equation

HRID 1831175 reaction equation
[C:1]([C:4]1[CH:12]=[C:8]([C:9]([NH2:11])=[O:10])[C:7]([OH:13])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[CH3:14][N:15]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:16](Cl)=[O:17]>>[C:1]([C:4]1[CH:5]=[CH:6][C:7]([O:13][C:16](=[O:17])[N:15]([CH3:14])[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[C:8]([C:9](=[O:10])[NH2:11])[CH:12]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 77969Carbamic chloride, N-methyl-N-phenyl-HCID 1982125-Acetylsalicylamide

Product 1

HCID 69518900Methyl-phenyl-carbamic Acid 4-acetyl-2-carbamoyl-phenyl Ester

Procedure

The title product was prepared from 5-acetylsalicylamide and N-methyl-N-phenylcarbamoyl chloride. The crude product was subjected to preparative HPLC. (87%, white solid). HPLC-MS: m/z=313.1 (M+1); Rt: 2.51 min.

Sources & evidence

ORD record
ord-5f6f4f3f47b54543a600c89b1625f681
Source dataset
uspto-grants-2006_06
Patent number
US07067517B2

Reaction notes

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