Trifluoroacetic acid → Trifluoroacetic acid

HRID 1831327ノート

反応式

HRID 1831327 の反応式
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17](=[O:26])[N:18]([CH3:25])[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:12][CH:11]=1)(C)(C)C.[C:28]([OH:34])([C:30]([F:33])([F:32])[F:31])=[O:29]>C(Cl)Cl>[NH2:7][CH2:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([O:16][C:17](=[O:26])[N:18]([CH3:25])[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[CH:14][CH:15]=1.[C:28]([OH:34])([C:30]([F:33])([F:32])[F:31])=[O:29]

参加物

5

反応物 2

HCID 6422Trifluoroacetic acidHCID 69518850{2-[4-(Methyl-phenyl-carbamoyloxy)-phenyl]-ethyl}-carbamic acid tertbutyl ester

生成物 2

HCID 6422Trifluoroacetic acidHCID 69520583Methyl-phenyl-carbamic acid 4-(2-amino-ethyl)phenyl Ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

{2-[4-(Methyl-phenyl-carbamoyloxy)-phenyl]-ethyl}-carbamic acid tertbutyl ester(3.7 g; 10 mmol) from above was dissolved in CH2Cl2 (90 mL). Addition of TFA (6 mL) and stirring for 4 h. The reaction mixture was evaporated to dryness and dried in vacuo at 50° C. overnight producing the title compound as a TFA salt in quantitative yield as yellow hygroscopic crystals.

後処理

  1. customThe reaction mixture was evaporated to dryness
  2. customdried in vacuo at 50° C. overnight

出典と根拠

ORDレコード
ord-88ed96cb6d4a4bb6b4891374aed81a5c
出典データセット
uspto-grants-2006_06
特許番号
US07067517B2

反応ノート

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