4-(Trifluoromethoxy)phenylboronic acid → Methyl-phenyl-carbamic Acid 4'-trifluoromethoxy-biphenyl-4-yl Ester

HRID 1831405Notes

Reaction equation

HRID 1831405 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:18])[N:10]([CH3:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.[F:19][C:20]([F:32])([F:31])[O:21][C:22]1[CH:27]=[CH:26][C:25](B(O)O)=[CH:24][CH:23]=1>>[F:19][C:20]([F:31])([F:32])[O:21][C:22]1[CH:27]=[CH:26][C:25]([C:2]2[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:18])[N:10]([CH3:17])[C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:4][CH:3]=2)=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 27343864-(Trifluoromethoxy)phenylboronic acidHCID 69517304Methyl-phenyl-carbamic Acid 4-iodo-phenyl Ester

Product 1

HCID 69519252Methyl-phenyl-carbamic Acid 4'-trifluoromethoxy-biphenyl-4-yl Ester

Procedure

The title compound was prepared from methyl-phenyl-carbamic acid 4-iodo-phenyl ester and 4-trifluoromethoxyphenylboronic acid. The crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane 1:9) (17%, brown oil).

Workup

  1. customThe crude product was purified by flash chromatography (Quad flash 12, EtOAc-heptane 1:9) (17%, brown oil)

Sources & evidence

ORD record
ord-1d93516c47b64461b89564ddd43c3992
Source dataset
uspto-grants-2006_06
Patent number
US07067517B2

Reaction notes

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