Triethylamine → HCID 22052034, compound

HRID 1831470Notes

Reaction equation

HRID 1831470 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][S:10][C:11]1[N:12]=[C:13](Cl)[C:14]2[S:19][C:18]([NH2:20])=[N:17][C:15]=2[N:16]=1.[CH3:22][CH2:23][CH2:24][CH2:25][CH:26]([NH2:29])[CH2:27][OH:28].C(N(CC)CC)C>>[NH2:20][C:18]1[S:19][C:14]2[C:13]([NH:29][CH:26]([CH2:25][CH2:24][CH2:23][CH3:22])[CH2:27][OH:28])=[N:12][C:11]([S:10][CH2:9][C:3]3[CH:4]=[CH:5][CH:6]=[C:7]([F:8])[C:2]=3[F:1])=[N:16][C:15]=2[N:17]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 249006DL-2-Amino-1-hexanolHCID 112216507-Chloro-5-[[(2,3-difluorophenyl)methyl]thio]-thiazolo[4,5-d]pyrimidin-2-amine

Product 1

HCID 22052034HCID 22052034, compound

Procedure

Prepared according to the procedure in Example 1, from 5-(2,3-difluorophenylmethylthio)-7-chloro-thiazolo[4,5-d]pyrimidin-2-ylamine (WO 00/09511) and DL-2-amino-1-hexanol, with triethylamine (one equivalent) added.

Workup

  1. customPrepared
  2. additionadded

Sources & evidence

ORD record
ord-fc41f68f1adb423ab5c3285aa31ce17e
Source dataset
uspto-grants-2006_06
Patent number
US07067657B2

Reaction notes

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