反应详情

[4-(2,4-Dichloro-phenyl)-3-nitro-pyridin-2-yl]-(2-methoxy-1-methyl-ethyl)-amine (0.20 g, 0.56 mmol was dissolved in dioxane (8 mL) and H2O (8 mL), followed by conc. NH4OH (0.3 mL) and Na2S2O4 (0.79 g, 4.53 mmol) and stirred at room temperature for 4 h. The solution was extracted with EtOAc, washed with H2O, brine, dried (Na2SO4), filtered, and concentrated in vacuo to produce 0.13 g (72%) of 4-(2,4-dichloro-phenyl)-N2-(2-methoxy-1-methyl-ethyl)-pyridine-2,3-diamine: MS (AP) m/z 326.2 [(M+H)+, 90].

1. extractionThe solution was extracted with EtOAc
2. washwashed with H2O, brine
3. dry with materialdried (Na2SO4)
4. filtrationfiltered
5. concentrationconcentrated in vacuo