HCID 22052297, compound → HCID 86584326, compound

HRID 1831680Notes

Reaction equation

HRID 1831680 reaction equation
[CH2:1]([CH:3]([NH:6][C:7]1[CH:12]=[C:11]([CH3:13])[N:10]=[C:9]([O:14][C:15]2[C:20]([CH3:21])=[CH:19][C:18]([CH3:22])=[CH:17][C:16]=2[CH3:23])[C:8]=1[OH:24])[CH2:4][CH3:5])[CH3:2].[Cl:25][CH2:26][C:27](Cl)=[O:28].C(N(CC)CC)C>C1COCC1>[CH2:1]([CH:3]([NH:6][C:7]1[CH:12]=[C:11]([CH3:13])[N:10]=[C:9]([O:14][C:15]2[C:20]([CH3:21])=[CH:19][C:18]([CH3:22])=[CH:17][C:16]=2[CH3:23])[C:8]=1[O:24][C:27](=[O:28])[CH2:26][Cl:25])[CH2:4][CH3:5])[CH3:2]

Participants

4

Reactant 2

HCID 22052297HCID 22052297, compoundHCID 86584327HCID 86584327, compound

Product 1

HCID 86584326HCID 86584326, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared by reacting 4-(1-ethyl-propylamino)-6-methyl-2-(2,4,6-trimethyl-phenoxy)-pyridin-3-ol with chloroacetyl chloride/triethylamine in THF at 0° C. to rt. 1H NMR(CDCl3) d 6.84(s,2H), 6.15(s,1H), 4.3(s,2H), 4.0(d,1H), 3.3(m,1H), 2.28(s,3H), 2.17(s,3H), 2.08(s,6H), ⅙–1.7(m,4H), 0.9(t,6H) ppm.

Workup

  1. customat 0° C. to rt

Sources & evidence

ORD record
ord-2a01a89435c14ce3839874f963e39d1c
Source dataset
uspto-grants-2006_06
Patent number
US07067664B1

Reaction notes

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