Lawesson's reagent → HCID 22052504, compound

HRID 1831744Notes

Reaction equation

HRID 1831744 reaction equation
[C:1]([O:5][C:6]([N:8]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([Cl:33])[CH:28]=1)[CH:9]([C:12]1[CH:13]=[CH:14][C:15]2[CH:16]3[CH2:25][CH2:24][CH2:23][CH:17]3[C:18](=O)[NH:19][C:20]=2[CH:21]=1)[CH2:10][CH3:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:43])=CC=1>C1COCC1>[C:1]([O:5][C:6]([N:8]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([Cl:33])[CH:28]=1)[CH:9]([C:12]1[CH:13]=[CH:14][C:15]2[CH:16]3[CH2:25][CH2:24][CH2:23][CH:17]3[C:18](=[S:43])[NH:19][C:20]=2[CH:21]=1)[CH2:10][CH3:11])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 22052509HCID 22052509, compound

Product 1

HCID 22052504HCID 22052504, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 260 mg (0.55 mmol) of 7-[1-(N-tert-butoxycarbonyl-3-chlorobenzylamino)propyl]-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one and 597 mg (1.48 mmol) of Lawesson's reagent in 30 ml of THF is refluxed for 1 hour. After concentration by evaporation in a vacuum, the residue is purified by column chromatography with hexane-ethyl acetate: 230 mg of product.

Workup

  1. concentrationAfter concentration
  2. customby evaporation in a vacuum
  3. customthe residue is purified by column chromatography with hexane-ethyl acetate

Sources & evidence

ORD record
ord-114a1156e5ae48b694a1d01b31fd491b
Source dataset
uspto-grants-2006_06
Patent number
US07067667B2

Reaction notes

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