Lawesson's reagent → HCID 22052533, compound

HRID 1831753Notes

Reaction equation

HRID 1831753 reaction equation
[C:1]([O:5][C:6]([N:8]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([Cl:33])[CH:28]=1)[CH:9]1[C:21]2[C:12](=[CH:13][C:14]3[CH:15]4[CH2:25][CH2:24][CH2:23][CH:16]4[C:17](=O)[NH:18][C:19]=3[CH:20]=2)[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:43])=CC=1>COCCOC>[C:1]([O:5][C:6]([N:8]([CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([Cl:33])[CH:28]=1)[CH:9]1[C:21]2[C:12](=[CH:13][C:14]3[CH:15]4[CH2:25][CH2:24][CH2:23][CH:16]4[C:17](=[S:43])[NH:18][C:19]=3[CH:20]=2)[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 22052519HCID 22052519, compound

Product 1

HCID 22052533HCID 22052533, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

A solution of 100 mg (0.21 mmol) of 7-(N-tert-butoxycarbonyl-3-chlorobenzyl-amino)-1,2,3,3a,7,8,9,10b-octahydro-dicyclopenta[c,g]quinolin-4-one and 96 mg (0.23 mmol) of Lawesson's reagent in 10 ml of DME is stirred for 2 hours at room temperature. After concentration by evaporation, the residue is purified by column chromatography on silica gel with hexane-ethyl acetate: 70 mg of product.

Workup

  1. concentrationAfter concentration
  2. customby evaporation
  3. customthe residue is purified by column chromatography on silica gel with hexane-ethyl acetate

Sources & evidence

ORD record
ord-8a76f14d49bb46c7b29ddf525f277aaf
Source dataset
uspto-grants-2006_06
Patent number
US07067667B2

Reaction notes

Loading…