Hydrochloric Acid → HCID 22052318, compound

HRID 1831761Notes

Reaction equation

HRID 1831761 reaction equation
C[O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=2[Cl:20])[CH:5]=1.[OH-].[Na+].O.Cl>O1CCOCC1>[Cl:20][C:14]1[CH:15]=[C:16]([Cl:19])[CH:17]=[CH:18][C:13]=1[CH2:12][CH2:11][O:10][C:6]1[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=1)[C:3]([OH:21])=[O:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 69652275HCID 69652275, compound

Product 1

HCID 22052318HCID 22052318, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
50 °C

Procedure

1 g (3.07 mmol) of 3-[2-(2,4-Dichlorophenyl)-ethoxy]-benzoic acid methyl ester was dissolved in 20 ml of dioxan. 2N aqueous NaOH was added to the solution to give a pH of 13. The reaction solution was heated at 50° C. for 3 h, and stirred at RT for 16 h. 5 ml water was added, followed by concentrated hydrochloric acid to give a pH of 1 to 2, whereupon the product precipitated from solution. The suspension was stirred for 30 min, then the product was filtered off and dried under reduced pressure.

Workup

  1. customto give a pH of 13
  2. customto give a pH of 1 to 2
  3. customwhereupon the product precipitated from solution
  4. stirringThe suspension was stirred for 30 min
  5. filtrationthe product was filtered off
  6. customdried under reduced pressure

Sources & evidence

ORD record
ord-7e5e66edbe5747e1b7c40bd1cbb290c6
Source dataset
uspto-grants-2006_06
Patent number
US07067665B2

Reaction notes

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