反应详情

1.5 g of 4′-formyl-biphenyl-2-sulfonic acid dimethylaminomethyleneamide prepared according to H. Jendralla et al. (Liebigs Ann. 1995, 1253–7) in 15 ml MeOH were treated with 208.6 mg NaCNBH3 and the reaction was stirred for 4 hours at RT. The pH was adjusted to 4.0, the reaction was filtered, the solvent was removed under reduced pressure and the residue was chromatographed on silica gel eluting with a gradient of 10–20% MeOH in DCM.

1. filtrationthe reaction was filtered
2. customthe solvent was removed under reduced pressure
3. customthe residue was chromatographed on silica gel eluting with a gradient of 10–20% MeOH in DCM